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In 2011, the Bohn lab mentioned antinociception against both chemically induced and inflammation-derived pain, and experiments indicated not enough opioid receptor modulation, but ended up not able to outline a selected concentrate on.
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[4] Molecular and pharmacological aspects of piperine as a potential molecule for disorder avoidance and administration: proof from medical trials
In addition, the conolidine molecule didn't communicate with the classical receptors, which means that it wouldn't compete against opioid
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